2022 – Best sleep duration – study from china

Original title

The brain structure and genetic mechanisms underlying the nonlinear association between sleep duration, cognition and mental health

Published: 28.04.2022

Screenshot of article best sleep time duration in nature aging
Screenshot

Our Speed summary

The aim of this study was to find out the best sleep duration. Scientists from the Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China, have examined data from nearly 500,000 adults between the ages of 38 and 73 in a study, collected in the UK Biobank database. As a result, an best sleep duration of 7h is recommended.

Original Abstract

Citation

Sleep duration, psychiatric disorders and dementias are closely interconnected in older adults. However, the underlying genetic mechanisms and brain structural changes are unknown. Using data from the UK Biobank for participants primarily of European ancestry aged 38–73 years, including 94% white people, we identified a nonlinear association between sleep, with approximately 7 h as the optimal sleep duration, and genetic and cognitive factors, brain structure, and mental health as key measures. The brain regions most significantly underlying this interconnection included the precentral cortex, the lateral orbitofrontal cortex and the hippocampus. Longitudinal analysis revealed that both insufficient and excessive sleep duration were significantly associated with a decline in cognition on follow up. Furthermore, mediation analysis and structural equation modeling identified a unified model incorporating polygenic risk score (PRS), sleep, brain structure, cognition and mental health. This indicates that possible genetic mechanisms and brain structural changes may underlie the nonlinear relationship between sleep duration and cognition and mental health.

Source

Li, Y., Sahakian, B.J., Kang, J. et al. The brain structure and genetic mechanisms underlying the nonlinear association between sleep duration, cognition and mental health. Nat Aging (2022). https://doi.org/10.1038/s43587-022-00210-2